MEDICAL MYCOLOGY

Dr Tadayo Hashimoto M.D.
Professor
Department of Microbiology & Immunology

13. Acquired resistance to coccidioidomycosis is demonstrated by:

elevated levels of humoral antibody
an immediate wheal reaction following an intradermal injection of coccidioidin
a positive tuberculin reaction
delayed hypersensitivity to coccidioidin
a negative reaction to coccidioidin

(D) A delayedtype hypersensitivity reaction is elicited when a mycelial culture filtrate (coccidioidin) is injected cutaneously. The skin test becomes positive within 2 weeks after the onset of symptoms and before the appearance of precipitins and complementfixing antibodies and often remains positive indefinitely. A positive test in healthy subjects implies immunity to symptomatic reinfection. All other reactions or findings cannot be correlated to acquired resistance to coccidioidomycosis. (Joklik et al, p. 1095; Ryan et al, pp. 607-611)

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