Idiopathic interstitial fibrosis is a disease characterized by diffuse interstitial fibrosis of unknown etiology and frequently occurs between the ages of 50-70.

Clinical Picture


Desquamative Interstitial pneumonitis(DIP), Usual Interstitial Pneumonitis(UIP), Lymphocytic Interstitial Pneumonitis( LIP) are various subgroups, probably of the same disease process.

  1. Early IPF: Desquamation predominates where alveolar macrophages fill alveolar spaces (desquamative interstitial pneumonitis or DIP).

  2. Late IPF: Inflammation of alveolar walls continues and fibroblast proliferation with collagen formation occurs (usual interstitial pneumonitis or UIP).