A fibrotic lung disease that primarily affects the small conducting airways and spares most of the interstitium.
Pathology: epithelial injury with a repair process causing an excessive proliferation of granulation tissue which compromises or completely obliterates the airway lumen.
Physiology: obstructive or restrictive ventilatory defect.
CXR: airspace and/or interstitial changes.
Bronchiolitis obliterans of known etiology
Toxic Fume Inhalation (S02, N02, NH3)
Steroids occasionally helpful.
Postinfectious Bronchiolitis Obliterans
RSV most common cause in infants and young children.
Mycoplasma, legionella and several viruses most common cause in adults.
Bronchiolitis obliterans of unknown etiology
Bronchiolitis Obliterans and Organizing Pneumonia
Also known as BOOP.
Connective Tissue Disease
Rheumatoid arthritis, systemic lupus, polymyositis and dermatomyositis, Sjogren's syndrome.
Bone marrow transplantation
- May occur in 10% of long-term survivors.
- May occur in 30-50% of long-term survivors.
Associated with other disease