Sarcoidosis is a pathologic condition which affects multiple organs
and is characterized by the presence of noncaseating granulomas.
- The characteristic, but not pathognomonic, histologic finding is the noncaseating
- Healing of the granuloma results in fibrosis and hyalinization.
- Granulomas often contain Schaumann's bodies and asteroid bodies. Refer to Figures
15-33 and 15-34 in your textbook.
- Although any organ or tissue may be involved with granulomas, the lungs,
peri-hilar lymph nodes and mediastinal lymph nodes are very common sites. Pulmonary
interstitial fibrosis may occur.
- Involvement of the spleen, liver, bone marrow, skin, eye and salivary glands is
More common in women and African-Americans.
Patients commonly present with respiratory abnormalities, constitutional findings (fever,
fatigue, weight loss, anorexia, night sweats) or a routine chest x-ray with bilateral
hilar adenopathy. Clinical finding may be unique to the organ involved, e.g. skin or eye.