Sensitivities and Specificities for Some Diagnostic Tests |
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Reference | Target disorder (and gold standard) |
Type of Patient | Diagnostic data | Sensitivity PiD rate TP rate |
Specificity Nill rate TN rate |
(28) |
Ulcer, hiatus hernia,abnormal mobility, or other important finding (by radiography) | Patients referred for an upper gastrointestinal series | History of ulcer, over age 50, pain relieved by food or milk, or pain after eating | 95% SnNOUT? |
30% |
(6) | Alcohol dependency or abuse (by extensive clinical investigation) | Medical and orthopedic inpatients | Gama-glutamyl transpeptidase Mean corpuscular volume Liver function tests "Yes" to 1 or more of the 4 CAGE questions "Yes" to 3 or more of the 4 CAGE questions |
54% 63% |
76% 64% |
(27) | Recovery with moderate to no disability (by follow-up) | Patients with nontraumatic coma | Corneal reflex | 92% | 35% |
(26) | Increased intracranial pressure(by lumbar puncture, surgery, or imaging) | Patients and volunteers | Absence of spontaneous pulsation of the retinal vein | 100% SnNout! |
85% |
(20) |
Iron deficiency anemia (by bone marrow aspiration) | Consecutive hospital admissions >65 years old | Red cell protoprophyrin Mean red cell volume Transferrin saturation Serum ferritin |
68% 72% 62% 82% |
68% 68% 86% 90% |
(23) | Deep vein thrombosis (by venography) | Patients with symptoms suggesting deep vein thrombosis | One or both of impedance plethysmography and 125l-fibrinogen leg scanning | 92% | 92% |
(17) | Pancreas cancer (by biopsy, surgery, or autopsy) | Patients with symptoms or signs suggesting cancer of file pancreas | Ultrasound (when successful) CT scan Endoscopic retrograde cholangio-pancretography (when successful) |
70% 85% 95% |
85% 90% 97% |