Pathogenesis of Tuberculosis

Inhalation: Contaminated Dusts or Droplets

Ingestion: Contaminated Milk (Uncommon in the Western World) - Tuberculosis Due to M. Bovis.

Spread, Multiplication and Damage

Tubercle bacilli do not produce exotoxins or endotoxin. The severe manifestations of tuberculosis are linked to host reactions to the organisms; damage is caused by uncontrolled, progressive, chronic inflammation, and by organisms living with macrophages. It follows that infection has different manifestations in a "virgin" host than in a person who has been infected previously. Tuberculosis manifests itself in two major forms: