The progressive maturation of a keratinocyte is charcterized by the accumulation of keratin, called keratinization. The cells of the stratum granulosum (SGR) accumlate dense basophilic keratohyalin granules (seen on the close-up view). These granules contain lipids, which along with the desmosomal connections, help to form a waterproof barrier that functions to prevent fluid loss from the body.
