1. Which one of the following statements concerning sarcoidosis is FALSE? Sarcoidosis is a granulomatous disease Incidence is most frequent in the elderly Skin lesions are commonly found The etiology remains unknown Treatment with antibiotics is not effective
2. Which one of the following statements concerning the diagnosis of sarcoidosis is TRUE? Definitive diagnosis is based on the histology of transbronchial biopsy tissue The diagnosis is based on serial angiotensin converting enzyme (ACE) levels The chest radiograph is normal at the time of diagnosis in most patients Normal pulmonary function studies exclude the diagnosis of sarcoidosis The diagnosis is based on combined clinical, radiologic, histologic findings
3. Which one of the following statements concerning granulomatous disease is TRUE? Granulomatous disease is characterized by acute inflammation Granulomatous disease is defined by a specific histologic pattern Malignant neoplasms do not cause granulomatous disease Bacterial infections do not cause granulomatous disease Lymph nodes containing granulomas are seldom enlarged
4. Signs and symptoms due to sarcoidosis occur LEAST often in relation to which of the following organs? the eye the skin the upper gastrointestinal tract the lungs the heart
5. Which of the following findings is MOST often seen on chest radiographs in patients with sarcoidosis? Normal chest radiograph Bilateral symmetric hilar lymphadenopathy Mediastinal lymphadenopathy with normal hila Bilateral pleural effusions Multiple lung masses
6. Computed tomography (CT) is accurately described by all of the following statements EXCEPT one. CT is more sensitive than radiographs in showing interstitial lung disease CT commonly demonstrates small lung nodules when sarcoidosis involves the lung Sarcoidosis involving the lung on a CT study can resemble lymphangitic lung metastasis Sarcoidosis often shows lung lesions which are distributed along the path of the bronchovascular bundles CT seldom shows thoracic lymphadenopathy that is not visible on radiographs.
7. Which one of the following statements concerning sarcoidosis is TRUE? The liver is seldom involved histologically A majority of patients have spleen lesions on CT studies Intra-abdominal and retroperitoneal lymphadenopathy are rare Heart involvement most often causes conduction defects and arrhythmias Sarcoidosis is not associated with fever
8. Which one of the following statements concerning sarcoidosis is FALSE? Presentation with polyarthritis, erythema nodosum, fever, and bilateral hilar lymphadenopathy is known as Lofgren's syndrome Sarcoidosis is characterized by an abnormal immune response which is related to T-cell lymphocytes The disease is often first discovered because of an abnormal chest radiograph in a patient with few or no symptoms despite widespread radiographic lesions Sarcoidosis can cause osteolytic bone lesions, most often in the hands and feet and most often in patients who have chronic skin lesions Sarcoidosis affects the reticuloendothelial system including lymph nodes, the liver and the spleen, but not the bone marrow
9. One of the following statements regarding lymphadenopathy in sarcoidosis is FALSE? Lymphadenopathy is the most common abnormal finding on chest radiographs There are often palpable neck or peripheral lymph nodes on physical examination Enlarged intra-abdominal and retroperitoneal lymph nodes are rare Enlarged lymph nodes usually regress spontaneously in months to years Thoracic lymphadenopathy can closely resemble lymphoma on imaging studies
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